A Memetic Algorithm for Multiple-Drug Cancer Chemotherapy Schedule Optimization

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Periodic Chemotherapy Dose Schedule Optimization Using Genetic Algorithm

This paper presents a design method for optimal cancer chemotherapy schedules using genetic algorithm (GA). The main objective of chemotherapy is to reduce the number of cancer cells or eradicate completely, if possible, after a predefined time with minimum toxic side effects which is difficult to achieve using conventional clinical methods due to narrow therapeutic indices of chemotherapy drug...

متن کامل

A Memetic Algorithm to Schedule Planned Grid Maintenance

The combination of local search operators with a genetic algorithm has provided very good results in certain scheduling problems, particularly in timetabling and other maintenance scheduling problems. In fact, in previous work, the local search operators alone have been seen to produce good quality results for the thermal generator maintenance scheduling problem. However, even better results ha...

متن کامل

Chemotherapy dosing schedule influences drug resistance development in ovarian cancer.

Drug resistance leads to chemotherapy failure and is responsible for the death of a great majority of patients with metastatic, late-stage ovarian cancer. The present study addressed whether changes in the chemotherapy dosing schedule affect the development, further worsening, or circumvention of drug resistance in chemosensitive and chemoresistant ovarian cancer. Severe combined immunodeficien...

متن کامل

Memetic Algorithm for Dynamic Optimization Problems

Dynamic optimization problems has attracted much attention of researchers. However, due to complexity and uncertainty to solve dynamic optimization problems, it very difficult to find out the optimum solution that could be changed over time. Thus, it is necessary to develop efficient or improved an algorithms to solve dynamic optimization problems. A memetic algorithm that based on local search...

متن کامل

Drug Cocktail Optimization in Chemotherapy of Cancer

BACKGROUND In general, drug metabolism has to be considered to avoid adverse effects and ineffective therapy. In particular, chemotherapeutic drug cocktails strain drug metabolizing enzymes especially the cytochrome P450 family (CYP). Furthermore, a number of important chemotherapeutic drugs such as cyclophosphamide, ifosfamide, tamoxifen or procarbazine are administered as prodrugs and have to...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: IEEE Transactions on Systems, Man and Cybernetics, Part B (Cybernetics)

سال: 2007

ISSN: 1083-4419

DOI: 10.1109/tsmcb.2006.883265